The usual adult dose of AMINOLEBAN® is 500 - 1000 mL per dose by intravenous drip infusion. The usual peripheral infusion rate is 500 mL over 180 - 300 minutes in adults (approx. 25 - 40 drops per minute). For total parenteral nutrition, 500 - 1000 mL of the injection should be suitable combined with dextrose or other solutions and administered over 24 hours via the central vein. The dosage may be adjusted depending on the patient's age, symptoms and body weight.
Treatment of hepatic encephalopathy in patients with chronic liver disease.
L-Threonine
2.25
g
L-Leucine
5.50
L-Serine
2.50
L-Phenylalanine
0.50
L-Proline
4.00
L-Tryptophan
0.35
L-Cysteine HCl H20
0.20
L-Histidine HCl H20
1.60
(L-Cysteine equivalent
0.15
g)
(L-Histidine equivalent
1.20
Aminoacetic acid
4.50
Lysine HCl
3.80
L-Alanine
3.75
(L-Lysine equivalent
3.05
L-Valine
4.20
L-Arginine HCl
3.65
L-Methionine
(L-Arginine equivalent
3.00
L-Isoleucine
Water for injection
Ad 500
mL
Amino acids - 7.99% (w/v) Total Nitrogen 12.2 g/L
Branched-chain amino acid - 35.5% (w/w) Cl- Approx. 94 mEq/L
Fischer's ratio* - 37.05 Na+ Approx. 12 mEq/L
E/N ratio - 1.09 Osmolarity Approx. 768 mOsm/L
* Molar ratio of (L-Valine + L-Leucine + L-Isoleucine) / (L-Tyrosine + L-Phenylalanine) Sodium bisulfite 0.3 g/L is used as a stabilizer.